منابع مشابه
Rediscovering Thalidomide
Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clini...
متن کاملImmunomodulation by thalidomide and thalidomide analogues.
Tumour necrosis factor á (TNFá), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFá in these clinical settings, strategies for the inhibition of this cytokine have been developed. Our previous work has shown that the drug thalidomide is a partial inhibitor of TNFá p...
متن کاملRethinking thalidomide.
Rethinking Thalidomide New research indicates that the controversial drug thalidomide, which caused severe birth deformities when taken as a sedative and hypnotic by pregnant women in the 1960s, may be useful in treating diseases that cause blindness. Robert D'Amato, a researcher at the Children's Hospital at Harvard Medical School, came across thalidomide while searching for drugs to treat two...
متن کاملThalidomide in ankylosing spondylitis.
Despite potential side effects dominated by teratogenicity and peripheral neuropathy, thalidomide has recently been used to treat severe ankylosing spondylitis (AS). Over 50 patients have been treated across several 6-12 month open studies. Altogether 68% of the patients improved and the drop-out rate was 19%. Inhibition of NF-kappaB and/or TNFalpha is a putative mechanism for thalidomide effic...
متن کاملAutism in Thalidomide
In the late 1950s thalidomide was synthesized and independently introduced in Germany, Great Britain and Japan as a potent sedative drug with few negative side-effects. In 1961 reports came from Germany, Australia and Great Britain (Kosenow and Pfeiffer 1961, MsBride 1961, Wiedeman 1961, Lenz 1962, Smithells 1962) that children were being born with serious malformations that might be associated...
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ژورنال
عنوان ژورنال: Science
سال: 1966
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.154.3754.1362